Publications
Highlights:
| Dendritic organization of sensory input to cortical neurons in vivo | |
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| Hongbo Jia*, Nathalie L. Rochefort*, Xiaowei Chen & Arthur Konnerth | |
| Nature 464, 1307-1312 (29 April 2010) | |
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In sensory cortex regions, neurons are tuned to specific stimulus features. For example, in the visual cortex, many neurons fire predominantly in response to moving objects of a preferred orientation. However, the characteristics of the synaptic input that cortical neurons receive to generate their ... Read more.. Comment: News and Views by Priebe NJ, Ferster D. |
| Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. | |
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| Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H. | |
| PLoS One. 2009 Nov 20;4(11):e7931. | |
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BACKGROUND: Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited b ... Read more.. |
| Sparsification of neuronal activity in the visual cortex at eye-opening. | |
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| Rochefort NL, Garaschuk O, Milos RI, Narushima M, Marandi N, Pichler B, Kovalchuk Y, Konnerth A. | |
| Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15049-54. | |
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Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integrate visual information. Here we used in vivo two-p ... Read more.. |
| Fenestration of the Calyx of Held Occurs Sequentially Along the Tonotopic Axis, Is Influenced by Afferent Activity, and Facilitates Glutamate Clearance | |
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| Ford MC, Grothe B, Klug A. | |
| J Comp Neurol. 2009 May 1;514(1):92-106. | |
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The calyx of Held is a type of giant glutamatergic presynaptic terminal in the mammalian auditory brainstem that transmits afferent information from the cochlear nucleus to the medial nucleus of the trapezoid body (MNTB). It participates in sound localization, a process that requires very high tempo ... Read more.. |
| Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease | |
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| Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O. | |
| Science. 2008 Sep 19;321(5896):1686-9. | |
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The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was ... Read more.. |
| TRPC3 channels are required for synaptic transmission and motor coordination. | |
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| Hartmann J, Dragicevic E, Adelsberger H, Henning HA, Sumser M, Abramowitz J, Blum R, Dietrich A, Freichel M, Flockerzi V, Birnbaumer L, Konnerth A. | |
| Neuron. 2008 Aug 14;59(3):392-8. | |
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In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not ... Read more.. |
| Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants | |
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| Kerschensteiner M, Reuter MS, Lichtman JW, Misgeld T. | |
| Nat Protoc. 2008;3(10):1645-53. | |
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We provide a protocol that describes an explant system that allows the dynamics of motor axons to be imaged. This method is based on nerve-muscle explants prepared from the triangularis sterni muscle of mice, a thin muscle that covers the inside of the thorax. These explants, which can be maintained ... Read more.. |
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